AtmosLM™ Probes


Pressure Cancelling Microdialysis Probes for Large Molecule, Neuropeptide, Cytokine and Protein Recovery.

AtmosLM™ Microdialysis Probes feature:

  • Large pore membranes for better recovery of large molecules such as antibodies, neuropeptides and cytokines.
  • A vent hole at the head of the probe for pressure equalization inside the membrane with outside atmospheric pressure.

Eicom’s patented design eliminates the leakage (ultrafiltration) challenges associated with large pore membranes when under pressure, prevalent in large molecule recovery with Microdialysis.

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Microdialysis Probes for Large Molecule Detection

Variety of sizes available depending on your target molecule

Microdialysis probes with a patented design allow researchers to quantify molecules that are not usually easy to detect.

User Reported Detectable Molecules with in Vivo Use

  • Amyloid β1-40 (4 kDa)
  • Monoclonal antibodies
  • ApoE particles (>200 kDa)
  • IL-1 β (17 kDa)
  • IL-6 (26 kDa)
  • Tau Protein (>50 kDa)
  • TNF-α (17 kDa)
  • CRF (5 kDa)
  • α-synuclein (14 kDa)

Membrane Types:

Polyethylene (PE) Membrane with 1,000 kDa Cut Off, 0.44 mm outer diameter.

Variety of Sizes Available for AtmosLM™ Microdialysis Probes

Aside from the Pressure Canceling Technology, the AtmosLM™ Microdialysis Probe, model PEP, is similar to our AZ microdialysis probes. We carry standard sizes of 4, 8 or 12 mm for the shaft length (X mm) and 1, 2, 3 or 4 mm for the membrane length (Y mm). Other sizes are available.

System Requirements

To collect the sample from the probe, a “pull” pump is required in addition to the infusion syringe pump. Eicom has developed a new peristaltic pump, the ERP-10, specifically for the AtmosLM™ system. The ERP-10 completes the AtmosLM™ system offered by Eicom, an incredibly convenient large molecule sampling system. The tubing from the syringe pump to the PEP-probes should be 0.1 mm ID (JT-10 or WT-35). The tubing from the PEP probe to the ERP-10 should be 0.25 mm ID (JF-10 or WT-35). The WT-35 has two tubes covered by a protective sheath. One tube is 0.1 mm ID (inlet) and  the second is 0.25 mm ID (outlet). Please download the manual for more details.

Microdialysis Options

The FC-90 Fraction Collector provides refrigerated fraction collection from up to four probes simultaneously. The samples are stored in a 96 well plate with resealing plate seals to prevent evaporation and cross contamination of samples.

The RCS-91 rotating cage stage and balance arm obviates the need for swivels: when the animal rotates, the stage rotates in the opposite direction to eliminate twisting in the animal’s tether. The RCS-91 also obviates the need for electrical and optical slip rings, leading to easier to combination of microdialysis, electrophysiology, and optogenetic equipment in the same experiment.




Bundle Contents

Microdialysis Probe Probe to allow molecules to go through. Has a vent to prevent internal pressure from exceeding atmospheric pressure.
Guide Cannula Guide for insertion of probes.
Dummy Cannula Prevents CSF from flowing into guide cannula during animal recovery.
Stereotaxic tool Used for guide cannula implantation.
Tubing (Inflow and Outflow) Inflow tubing is narrower than outflow tubing to reduce pressure.
Cap Nuts Used to anchor the dental cement for secure connection of microdialysis probe to guide cannula.
Syringe Pump Used before the probe to push molecules. AtmosLM uses both pumps.
Roller Pump Used after the probe to pull molecules. AtmosLM uses both pumps.
Fraction Collector Sample collection.